The purpose of the study was to develop the sustained release of bilayered tablets. Bilayered tablets are preferred when the release profile of the drugs are different from one another. In this studies combination of Salbutamol sulphate and Theophylline are used which shows synergistic effect in producing bronchodilation. The formulations were prepared by using HPMC-P, Ethyl cellulose and HPMCK100M as polymers at various concentrations. The bilayered matrix tablets were prepared by wet granulation method. The prepared tablets were evaluated for hardness, drug content and Invitro dissolution studies. All the formulations showed good matrix integrity and sustained release of drug for 8hrs. In F13 formulation theophylline release was 13.20% in the 1st hour and in 8th hour 99.62% and Salbutamol sulphate release was 46.6%in the 1st hour and only 96.26% in the 8th hour. So it can be concluded that the formulation (F13) which containing HPMC-P polymer is suited for the sustained release matrix tablets of Salbutamol sulphate and Theophylline.
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